Friday, July 31, 2015

A research study on hypothyroidism and miscarriage.- Dr Sanjana vb

A research study on hypothyroidism and miscarriage.-

-Dr Sanjana vb
[SIAHMSR] - academy &research wing of Serenity global homeopathy.


Hypothyroidism and subclinical hypothyroidism  in women interfere with fecundity and cause miscarriage.The statistics of female infertility is given in the table below.Based on this data a retrospective study was done by Dr Sanjana from 2007 to 2014 in mothers  with history of hypothyroidism and subclinical hypothyroidism or gestational hypothyroidism. The study outcome and management protocols evolved is described here.

Literature review



In Table 14-4, the information available from thirteen studies investigating the risk of a miscarriage in relation with the presence (versus the absence) of AITD has been compiled .  The overall risk of having a miscarriage was 3-fold to 5-fold greater in women with AITD (and apparent euthyroidism). In another review by Stagnaro-Green & Glinoer in 2004, a classification was attempted by examining separately an association between AITD & miscarriage (in 5 studies), between AITD & recurrent miscarriage (in 7 studies), and finally between AITD & early pregnancy loss after ART (in 5 studies) . Overall and with only few exceptions, all studies documented a statistically significant relationship between thyroid autoimmunity and an increased risk of pregnancy loss. Finally in 2004, Prummel & Wiersinga published a meta-analysis of both the case-controlled and longitudinal studies published since 1990, after the association between miscarriage and AITD was first described 179. The results of this meta-analysis amply confirmed that an association exists, with an overall increased relative risk of a miscarriage of 2.73 in women with AITD. Table 14-4 Miscarriages in women with positive thyroid antibodies
First author
Year
Country
Number of subjects
Positive thyroid antibodies
Miscarriage rate

P value
Stagnaro-Green
1990
U. S. A.
552
19.6 %
17.0 % vs
8.4 %
= 0.011
unselected population study
Glinoer
1991
Belgium
726
6.2 %
13.3 % vs
3.3 %
< 0.005
unselected population study
Lejeune
1993
Belgium
363
6.3 %
22.0 % vs
5.0 %
< 0.005
unselected population, before 14 wks gestation
Pratt
1993
U. S. A.
42
31.0 %
67.0 % vs
33.0 %
n.a.
recurrent spontaneous abortions
Singh
1995
U. S. A.
487
22.0 %
32.0 % vs
16.0 %
= 0.002
pregnant with assisted reproductive techniques
Bussen
1995
Germany
66
17.0 %
36.0 % vs
7.0 %
< 0.03
recurrent spontaneous abortions
Iijima
1997
Japan
1179
10.6 %
10.4 % vs
5.5 % <
0.05
unselected population study
Esplin
1998
U. S. A.
149
33.0 %
29.0 % vs
37.0 % >
0.05
recurrent pregnancy loss
Kutteh
1999
U. S. A.
900
20.8 %
22.5 % vs
14.5 %
= 0.01
two or more consecutive abortions
Muller
1999
Netherlands
173
14.0 %
33.0 % vs
19.0 %
= 0.29
pregnant with assisted reproductive techniques
Bussen
2000
Germany
48
30.6 %
54.2 % vs
8.3 %
= 0.002
failure to conceive after 3 cycles of IVF
Dendrinos
2000
Greece
45
32.5 %
37.0 % vs
13.0 %
< 0.05
recurrent spontaneous abortions
Bagis
2001
Turkey
876
12.3 %
50.0 % vs
14.1 %
< 0.0001
unselected population study




 A retrospective study conducted by Dr Sanjana vb   BHMS   also found out that autoimmune thyroiditis has definite role in limiting the chances of fertility or causing abortion.  Based on this study result the etiology of autoimmunity was studied meticulously and the outcome pointed out that prolonged exposure to stress is one of the major triggers for autoimmunity in women. Since 2007 she studied the effect of some homeopathic drugs in curing thyroid problems in women with history of severe stress &emotional outbursts for a prolonged period of time. The study has thrown some light into the effect of stress related AITD as a major cause of abortions .Stress triggers hyper secretion of cortisol hormone in our body and the cascade of events ultimately lead to excess conversion of T4 to reverse T3 hormone or RT3 production. RT3 is thought to be the culprit for hypothyroidism in AITD women.  Homeopathy has definite treatment protocols for curing stress, autoimmune thyroiditis and hence abortion or infertility in sub clinical hypothyroid [SCH] and overtly hypothyroid [OH] women.[ Date of study – May2007 to June  2014]


       a systematic review of  untreated gestational hypothyroidism gave substantial evidence regarding the role of maternal hypothyroidism due to AITD [AUTOIMMUNE THYROIDITIS] for the psycho-neurological outcome in the progeny

        Several clinical studies have investigated the psychological and intellectual outcome in the offspring of pregnant women with thyroid insufficiency, both in conditions of hypothyroidism with an adequate iodine nutritional status and women with mild-moderate iodine deficiency. Overall, the results show that there is a significantly increased risk of impairment in neuro-psychological developmental indices, IQ scores, and school learning abilities in the offspring of untreated hypothyroid mothers.
Homeopathy has treatment protocols for addressing both hypothyroidism in women of reproductive age group and children presenting with psychological imbalance, anxiety, depression, lack of concentration consequent to maternal gestational hypothyroidism. It is very important that homeopathic management is effective only in women who are at the initial phases of autoimmune thyroiditis. Autoimmune attack for a prolonged time period can destroy the gland and thus limits the chances of recovery. 
[will be continued]

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