A research study on hypothyroidism and miscarriage.- Dr Sanjana vb

A research study on hypothyroidism and miscarriage.-

-Dr Sanjana vb
[SIAHMSR] - academy &research wing of Serenity global homeopathy.

Hypothyroidism and subclinical hypothyroidism  in women interfere with fecundity and cause miscarriage.The statistics of female infertility is given in the table below.Based on this data a retrospective study was done by Dr Sanjana from 2007 to 2014 in mothers  with history of hypothyroidism and subclinical hypothyroidism or gestational hypothyroidism. The study outcome and management protocols evolved is described here.

Literature review

In Table 14-4, the information available from thirteen studies investigating the risk of a miscarriage in relation with the presence (versus the absence) of AITD has been compiled .  The overall risk of having a miscarriage was 3-fold to 5-fold greater in women with AITD (and apparent euthyroidism). In another review by Stagnaro-Green & Glinoer in 2004, a classification was attempted by examining separately an association between AITD & miscarriage (in 5 studies), between AITD & recurrent miscarriage (in 7 studies), and finally between AITD & early pregnancy loss after ART (in 5 studies) . Overall and with only few exceptions, all studies documented a statistically significant relationship between thyroid autoimmunity and an increased risk of pregnancy loss. Finally in 2004, Prummel & Wiersinga published a meta-analysis of both the case-controlled and longitudinal studies published since 1990, after the association between miscarriage and AITD was first described 179. The results of this meta-analysis amply confirmed that an association exists, with an overall increased relative risk of a miscarriage of 2.73 in women with AITD. Table 14-4 Miscarriages in women with positive thyroid antibodies
First author	Year	Country		Number of subjects		Positive thyroid antibodies			Miscarriage rate
											P value
Stagnaro-Green		1990	U. S. A.		552	19.6 %	17.0 % vs	8.4 %		= 0.011		unselected population study
Glinoer		1991	Belgium		726	6.2 %	13.3 % vs	3.3 %		< 0.005		unselected population study
Lejeune		1993	Belgium		363	6.3 %	22.0 % vs	5.0 %		< 0.005		unselected population, before 14 wks gestation
Pratt		1993	U. S. A.		42	31.0 %	67.0 % vs	33.0 %		n.a.		recurrent spontaneous abortions
Singh		1995	U. S. A.		487	22.0 %	32.0 % vs	16.0 %		= 0.002		pregnant with assisted reproductive techniques
Bussen		1995	Germany		66	17.0 %	36.0 % vs	7.0 %		< 0.03		recurrent spontaneous abortions
Iijima		1997	Japan		1179	10.6 %	10.4 % vs	5.5 % <		0.05		unselected population study
Esplin		1998	U. S. A.		149	33.0 %	29.0 % vs	37.0 % >		0.05		recurrent pregnancy loss
Kutteh		1999	U. S. A.		900	20.8 %	22.5 % vs	14.5 %		= 0.01		two or more consecutive abortions
Muller		1999	Netherlands		173	14.0 %	33.0 % vs	19.0 %		= 0.29		pregnant with assisted reproductive techniques
Bussen		2000	Germany		48	30.6 %	54.2 % vs	8.3 %		= 0.002		failure to conceive after 3 cycles of IVF
Dendrinos		2000	Greece		45	32.5 %	37.0 % vs	13.0 %		< 0.05		recurrent spontaneous abortions
Bagis		2001	Turkey		876	12.3 %	50.0 % vs	14.1 %		< 0.0001		unselected population study

 A retrospective study conducted by Dr Sanjana vb   BHMS   also found out that autoimmune thyroiditis has definite role in limiting the chances of fertility or causing abortion.  Based on this study result the etiology of autoimmunity was studied meticulously and the outcome pointed out that prolonged exposure to stress is one of the major triggers for autoimmunity in women. Since 2007 she studied the effect of some homeopathic drugs in curing thyroid problems in women with history of severe stress &emotional outbursts for a prolonged period of time. The study has thrown some light into the effect of stress related AITD as a major cause of abortions .Stress triggers hyper secretion of cortisol hormone in our body and the cascade of events ultimately lead to excess conversion of T4 to reverse T3 hormone or RT3 production. RT3 is thought to be the culprit for hypothyroidism in AITD women.  Homeopathy has definite treatment protocols for curing stress, autoimmune thyroiditis and hence abortion or infertility in sub clinical hypothyroid [SCH] and overtly hypothyroid [OH] women.[ Date of study – May2007 to June  2014]

       a systematic review of  untreated gestational hypothyroidism gave substantial evidence regarding the role of maternal hypothyroidism due to AITD [AUTOIMMUNE THYROIDITIS] for the psycho-neurological outcome in the progeny

        Several clinical studies have investigated the psychological and intellectual outcome in the offspring of pregnant women with thyroid insufficiency, both in conditions of hypothyroidism with an adequate iodine nutritional status and women with mild-moderate iodine deficiency. Overall, the results show that there is a significantly increased risk of impairment in neuro-psychological developmental indices, IQ scores, and school learning abilities in the offspring of untreated hypothyroid mothers.

Homeopathy has treatment protocols for addressing both hypothyroidism in women of reproductive age group and children presenting with psychological imbalance, anxiety, depression, lack of concentration consequent to maternal gestational hypothyroidism. It is very important that homeopathic management is effective only in women who are at the initial phases of autoimmune thyroiditis. Autoimmune attack for a prolonged time period can destroy the gland and thus limits the chances of recovery. 
[will be continued]